The discovery of vitamin E will have its 100th anniversary in 2022, but we still have more
questions than answers regarding the biological functions and the essentiality of vitamin E …

Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor
microenvironment and inherent characteristics of brain tumor cells virtually render them …

Four tocopherols are available in nature and are absorbed with the diet, but only one RRR-α-
tocopherol satisfies the criteria of being a vitamin. The biological activity of the different …

Current observations in the literature suggest that vitamin E may be a suitable candidate for
the adjuvant treatment of cancer. Even though historically most research focused on α …

Vitamin E modulates signal transduction pathways by several molecular mechanisms. As a
hydrophobic molecule located mainly in membranes it contributes together with other lipids …

Vitamin E modulates the activity of several signal transduction enzymes with consequent
alterations of gene expression. At the molecular level, vitamin E may directly bind to these …

The pineal gland hormone melatonin has been recently described to downregulate the
intrinsic (or damage-induced) pathway of apoptosis in human leukocytes. These properties …

Glutathione S-transferase pi (GSTP), a phase II gene downstream of the nuclear factor
erythroid 2-related factor 2 (Nrf2)–antioxidant-responsive element (ARE)/electrophile …

Nearly after one century of research and thousands of publications, the physiological
function (s) of vitamin E remain unclear. Available evidence suggests a role in cell …

The eye is particularly susceptible to oxidative stress and disruption of the delicate balance
between oxygen-derived free radicals and antioxidants leading to many degenerative …