The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine
trials suggest an important role of inflammasomes and their major product IL-1β (interleukin …

Exposure of mitochondrial DNA (mtDNA) to the cytosol activates innate immune responses.
But the mechanisms by which mtDNA crosses the inner mitochondrial membrane are …

Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously
unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic …

Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to
hematopoietic stem cells and the outgrowth of clones of blood cells. Clonal hematopoiesis …

Background Nasopharyngeal carcinoma (NPC) is the most common subcategory of head
and neck squamous cell carcinoma (HNSCC). This study focused on the roles of cuproptosis …

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway is
mainly responsible for the activation and release of a cascade of proinflammatory mediators …

Post‑ischemic neuroinflammation induced by the innate local immune response is a major
pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of …

BACKGROUND: Clonal hematopoiesis (CH) has emerged as an independent risk factor for
atherosclerotic cardiovascular disease, with activation of macrophage inflammasomes as a …

Pharmacological inhibition of the Nod-like receptor family protein 3 (NLRP3) inflammasome
contributes to the treatment of numerous inflammation-related diseases, making it a …