Emerging evidence indicates that l-glutamine (Gln) plays a fundamental role in
cardiovascular physiology and pathology. By serving as a substrate for the synthesis of …

Abstract Type 2 diabetes (T2D) associated health disparities among different ethnicities
have long been known. Ethnic variations also exist in T2D related comorbidities including …

While obesity and associated metabolic complications are linked to inflammation of white
adipose tissue (WAT), the causal factors remain unclear. We hypothesized that the local …

Abstract Background Amino acids (AAs) are emerging as a new class of effective molecules
in the etiology of obesity and diabetes mellitus. However, most investigations have focused …

Aims/hypothesis The aims of this study were to evaluate systematically the predictive power
of comprehensive metabolomics profiles in predicting the future risk of type 2 diabetes, and …

Background Reduced serum level of taurine in type 2 diabetes mellitus (T2DM) was shown
to be associated with the metabolic alterations and clinical complications of diabetes …

Dysregulation of skeletal muscle metabolism influences whole-body insulin sensitivity and
glucose homeostasis. We hypothesized that type 2 diabetes–associated alterations in the …

Background and aims Glutamate, glutamine are involved in energy metabolism, and have
been related to cardiometabolic disorders. However, their roles in the development of type-2 …

Oxidative stress is an important contributor to the pathophysiology of sickle cell disease. The
pathways involved are complex and interlinked. L-glutamine is an amino acid with myriad …

Obesity and its associated conditions, such as nonalcoholic fatty liver disease (NAFLD), are
risk factors for health. The aim of this study was to explore the effects of glutamine (Gln) on …