Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

Epithelial tissue formation and function requires the apical-basal polarization of individual
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …

Abstract E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial
sheets. Through the homophilic association of E-Cadherin molecules expressed on …

PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and
enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They …

The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …

Apical–basal polarity is essential for the formation and function of epithelial tissues, whereas
loss of polarity is a hallmark of tumours. Studies in Drosophila have identified conserved …

Epithelial apico-basal polarity is established through the asymmetric cortical distribution of
the Par, Crumbs and Scribble polarity modules. Apical (Par and Crumbs) and basolateral …

Cdc42–a member of the small Rho GTPase family–regulates cell polarity across organisms
from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial …