Nowadays, the diagnosis and treatment system of malignant tumors has increasingly tended
to be more precise and personalized. And the existing tumor models are still unable to fully …

Patient‐derived organoid models hold promise for advancing clinical cancer research,
including diagnosis and personalized and precision medicine approaches, and cytology, in …

Organoids more accurately reflect tumor microenvironment than traditional models. Millen et
al. demonstrated organoids replicated from patient tissues may predict patient-specific …

Drug resistance that affects patients universally is a major challenge in cancer therapy. The
development of drug resistance in cancer cells is a multifactor event, and its process …

Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has
broadened the repertoire of preclinical models and progressively revolutionized three …

For several decades now, researchers have been trying to answer the demand of clinical
oncologists to create an ideal preclinical model of head and neck squamous cell carcinoma …

Cancer is associated with a high degree of heterogeneity, encompassing both inter-and
intra-tumor heterogeneity, along with considerable variability in clinical response to common …

Background There are relatively few widely used models of prostate cancer compared to
other common malignancies. This impedes translational prostate cancer research because …

Background Survival rates of head and neck squamous cell carcinoma (HNSCC) have only
marginally improved in the last decades. Hence there is a need for predictive biomarkers for …

Simple Summary The desire to reduce the use of animals in research and drug testing has
led to an upsurge in the development of 3-Dimensional models, which try and mimic parts of …