The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …

Importance of the field: Antipsychotic drug is the mainstay of treatment for schizophrenia,
and there are large inter-individual differences in clinical response and side effects …

Background Advances in personalized medicine require the identification of variables that
predict differential response to treatments as well as the development and refinement of …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Background Antipsychotic drugs improve schizophrenia symptoms and reduce the
frequency of relapse, but treatment response is highly variable. Little is known about the …

Objective As genotyping technology has progressed, genome-wide association studies
(GWAS) have matured into efficient and effective tools for mapping genes underlying human …

Objective: During the past decades, increasing efforts have been invested in studies to
unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response …

BACKGROUND: Autism spectrum disorders (ASDs) are characterized by social,
communication, and behavioral deficits and complex genetic etiology. A recent study of 517 …

Antipsychotic response in schizophrenia is a complex, multifactorial trait influenced by
pharmacogenetic factors. With genetic studies thus far providing little biological insight or …

Antipsychotic drugs targeting dopamine neurotransmission are still the principal mean of
therapeutic intervention for schizophrenia. However, about one third of people do not …