Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …

Polymer nanomedicines (macromolecular therapeutics, polymer-drug conjugates, drug-free
macromolecular therapeutics) are a group of biologically active compounds that are …

Stimuli-responsive peptide dendrimer-drug conjugates have presented significant potential
for cancer therapy. To develop an effective nanoscale chemotherapeutic prodrug, we …

Cathepsins are an important category of enzymes that have attracted great attention for the
delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug …

Combination therapy is one of the important treatment strategies for cancer at present.
However, the outcome of current combination therapy based on the co-administration of …

The phosphatidylinositol 3-kinase (PI3K)/serine-threonine kinase (Akt)/mammalian target of
the rapamycin (mTOR)-signaling pathway has been suggested to have connections with the …

To achieve effective chemotherapy, many types of drug delivery systems have been
developed for the specific environments in tumor tissues. Polymer–drug conjugates are …

Intraperitoneal chemotherapy was explored in clinical trials as a promising strategy to
improve the therapeutic effects of chemotherapy. In this work, we developed a …

The application of synthetic polymers as delivery systems of chemotherapy drugs has
opened a very prospective field for research in cancer therapy. Due to their unique and …

Cancer stem cells have been defined as cells within a tumor that possesses the capacity to
self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor …