The incidence of hepatocellular carcinoma (HCC) and the mortality resulting from HCC are
both increasing. Most patients with HCC are diagnosed at advanced stages when curative …

Rodents have been the dominant animal models in neurobiology and neurological disease
research over the past 60 years. The prevalent use of rats and mice in neuroscience …

Caveolae have been linked to many biological functions, but their precise roles are unclear.
Using quantitative whole-cell proteomics of genome-edited cells, we show that the oxidative …

Moderate or severe traumatic brain injury (TBI) causes widespread neuronal cell death.
Microglia, the resident macrophages of the brain, react to injury by migrating to the lesion …

Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network
support essential developmental processes and their disruption lead to neurodevelopmental …

Abstract Transactivating DNA-binding protein-43 (TDP-43) deposits represent a typical
finding in almost all ALS patients, more than half of FTLD patients and patients with several …

Vitamin D receptor (VDR) has been implicated in fatty liver pathogenesis, but its role in the
regulation of organismal energy usage remains unclear. Here, we illuminate the …

Tissue-wide coordination of polarized cytoskeletal organization and cell behaviour, critical
for normal development, is controlled by asymmetric membrane localization of non …

The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role
for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by …

The skeletal muscle T-tubule is a specialized membrane domain essential for coordinated
muscle contraction. However, in the absence of genetically tractable systems the …