Importance Most evidence about efficacy and safety of antipsychotics in schizophrenia
spectrum disorders relies on randomized clinical trials (RCTs). However, owing to their strict …

Abstract Background Pragmatic clinical trials (PCTs) are designed to reflect how an
investigational treatment would be applied in clinical practice. As such, unlike their …

Background Treatment of metastatic renal cell carcinoma (mRCC) is rapidly evolving with
new combination therapies demonstrating improved response rates and survival. There are …

Traditionally the gatekeeper to the NHS, NICE has increasingly reoriented its role towards
facilitating access to innovative technologies. This change has clear benefits for some …

Simple Summary Kidney cancer occurs more commonly within the general population and
has historically been associated with morbidity and early death. The most common form of …

Background New drugs for locally advanced or metastatic breast cancer have led to clinical
benefits, aside with increasing costs to healthcare systems. The current financing model for …

Importance The initial assessment of pertuzumab use for treatment of metastatic breast
cancer by health technology assessment agencies suggested that pertuzumab was not cost …

Introduction Clinical trials confirmed the beneficial effects of adding pertuzumab (P) to the
combination of trastuzumab-chemotherapy (TC) in the (neo) adjuvant setting of high-risk …

Aims Clinical practice guidelines recommend palliative chemotherapy for most patients with
metastatic colorectal cancer. However, outcomes observed in the real world compared with …

Background Tucatinib is an oral human epidermal growth factor receptor 2 (HER2)-directed
therapy approved in combination with trastuzumab and capecitabine for use in patients with …