The ability to take up substances from the surrounding environment not only provides cells
with vital nutrients, but also enables the selective transport of substances from one …

The multiligand, endocytic receptors megalin and cubilin are colocalized in the renal
proximal tubule. They are heavily expressed in the apical endocytic apparatus. Megalin is a …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …

We completed the cDNA cloning and sequencing of gp330, the major kidney glomerular
antigen for rat Heymann nephritis. The deduced 4660-aa sequence, expected to constitute a …

gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is
expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where …

▪ Abstract The low-density lipoprotein (LDL) receptor (LDL-R) family consists of cell-surface
receptors that recognize extracellular ligands and internalize them for degradation by …

Glycoprotein 330 (gp330) is an endocytic receptor expressed in the renal proximal tubules
and some other absorptive epithelia, eg, in the inner ear. The present study shows that the …

Membranous nephropathy (MN) describes a histopathologic pattern of injury marked by
glomerular subepithelial immune deposits and collectively represents one of the most …

Aminoglycosides such as gentamicin and amikacin are the most commonly used antibiotics
worldwide in the treatment of Gram-negative bacterial infections. However, serious …

Spinal muscular atrophies (SMAs) represent the second most common fatal autosomal
recessive disorder after cystic fibrosis. Childhood spinal muscular atrophies are divided into …