Immune checkpoint blockade in infectious diseases
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
T cell senescence and CAR-T cell exhaustion in hematological malignancies
D Kasakovski, L Xu, Y Li - Journal of hematology & oncology, 2018 - Springer
T cell senescence has been recognized to play an immunosuppressive role in the aging
population and cancer patients. Strategies dedicated to preventing or reversing replicative …
population and cancer patients. Strategies dedicated to preventing or reversing replicative …
TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells
T Sekine, A Perez-Potti, S Nguyen, JB Gorin… - Science …, 2020 - science.org
CD8+ T cell exhaustion is a hallmark of many cancers and chronic infections. In mice, T cell
factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection …
factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection …
TIGIT/CD226 axis regulates anti-tumor immunity
Tumors escape immune surveillance by inducing various immunosuppressive pathways,
including the activation of inhibitory receptors on tumor-infiltrating T cells. While monoclonal …
including the activation of inhibitory receptors on tumor-infiltrating T cells. While monoclonal …
Why and where an HIV cure is needed and how it might be achieved
Despite considerable global investment, only 60% of people who live with HIV currently
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
CD226: an emerging role in immunologic diseases
CD226, a member of the immunoglobulin superfamily, is a functional protein initially
expressed on natural killer and T cells. In recent years, the function of CD226 has been …
expressed on natural killer and T cells. In recent years, the function of CD226 has been …
The multifaceted nature of HIV latency
C Dufour, P Gantner, R Fromentin… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …
Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells
S Nguyen, C Deleage, S Darko, A Ransier… - Science translational …, 2019 - science.org
The functional properties of circulating CD8+ T cells have been associated with immune
control of HIV. However, viral replication occurs predominantly in secondary lymphoid …
control of HIV. However, viral replication occurs predominantly in secondary lymphoid …
CD226hiCD8+ T Cells Are a Prerequisite for Anti-TIGIT Immunotherapy
Clinical trials are evaluating the efficacy of anti-TIGIT for use as single-agent therapy or in
combination with programmed death 1 (PD-1)/programmed death-ligand 1 blockade. How …
combination with programmed death 1 (PD-1)/programmed death-ligand 1 blockade. How …
Defective HIV-1 genomes and their potential impact on HIV pathogenesis
J Kuniholm, C Coote, AJ Henderson - Retrovirology, 2022 - Springer
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …