The mitochondria are double-membrane organelles integral for energy metabolism.
Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane (IMM and …

Skeletal muscle atrophy is a well-known consequence of spaceflight. Because of the
potential significant impact of muscle atrophy and muscle dysfunction on astronauts and …

Background As a result of aging, skeletal muscle undergoes atrophy and a decrease in
function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia …

Sarcopenia is a debilitating skeletal muscle disease that accelerates in the last decades of
life and is characterized by marked deficits in muscle strength, mass, quality, and metabolic …

Abstract Background Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked
to longevity and has been suggested to confer beneficial effects that counter aging …

Space colonization represents the most insidious challenge for mankind, as numerous
obstacles affect the success of space missions. Specifically, the absence of gravitational …

Prolonged unloading of skeletal muscle, a common outcome of events such as spaceflight,
bed rest and hindlimb unloading, can result in extensive metabolic, structural and functional …

Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin
ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal …

Muscle disuse in the hindlimb unloaded (HU) mice causes significant atrophy and
weakness. However, the cellular and molecular mechanisms driving disuse-muscle atrophy …

Metabolism plays an important role in regulating aging at several levels, and metabolic
reprogramming is the main driving force of aging. Due to the different metabolic needs of …