The NR4A subgroup: immediate early response genes with pleiotropic physiological roles
MA Maxwell, GEO Muscat - Nuclear receptor signaling, 2006 - journals.sagepub.com
The nuclear hormone receptor (NR) superfamily includes the orphan NR4A subgroup,
comprised of Nur77 (NR4A1), Nurr1 (NR4A2) and NOR-1 (NR4A3). These NRs are …
comprised of Nur77 (NR4A1), Nurr1 (NR4A2) and NOR-1 (NR4A3). These NRs are …
The paradoxical roles of orphan nuclear receptor 4A (NR4A) in cancer
The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli,
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …
Nuclear receptor 4A (NR4A) family–orphans no more
S Safe, UH Jin, B Morpurgo, A Abudayyeh… - The Journal of steroid …, 2016 - Elsevier
The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …
Targeting nuclear receptors in neurodegeneration and neuroinflammation
S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …
expression upon ligand signals and present as attractive therapeutic targets especially in …
Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation
M Maira, C Martens, A Philips… - Molecular and cellular …, 1999 - Taylor & Francis
We have recently shown that the orphan nuclear receptor Nur77 (NGFI-B) is most active in
transcription when it is interacting with a cognate DNA sequence as a homodimer. Further …
transcription when it is interacting with a cognate DNA sequence as a homodimer. Further …
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway
KD Baker, LM Shewchuk, T Kozlova, M Makishima… - Cell, 2003 - cell.com
Ecdysteroid pulses trigger the major developmental transitions during the Drosophila life
cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor …
cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor …
Molecular insights into NR4A2 (Nurr1): an emerging target for neuroprotective therapy against neuroinflammation and neuronal cell death
NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …
Akt phosphorylates and regulates the orphan nuclear receptor Nur77
Y Pekarsky, C Hallas, A Palamarchuk… - Proceedings of the …, 2001 - National Acad Sciences
The immediate early gene NUR77 (also called NGFI-B) is required for T cell antigen
receptor-mediated cell death and is induced to very high levels in immature thymocytes and …
receptor-mediated cell death and is induced to very high levels in immature thymocytes and …
Nurr1‐based therapies for Parkinson's disease
Previous studies have documented that orphan nuclear receptor Nurr1 (also known as NR
4A2) plays important roles in the midbrain dopamine (DA) neuron development …
4A2) plays important roles in the midbrain dopamine (DA) neuron development …
The role of NR4A transcription factors in memory formation
In various physiological contexts, Nr4a genes are transcribed in response to external stimuli
as part of an immediate early response that initiates a cascade of gene expression ultimately …
as part of an immediate early response that initiates a cascade of gene expression ultimately …