Rapid advances in high-throughput sequencing and a growing realization of the importance
of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies …

The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been
systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients …

Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes
that have not been systematically studied to date. Here, we analyzed 575 primary and 335 …

The genomic evolution inherent to cancer relates directly to a renewed focus on the
voluminous next-generation sequencing data and machine learning for the inference of …

Motivation The evolution of bacterial drug resistance and other features in biology, the
progression of cancer and other diseases and a wide range of broader questions can often …

Circulating tumor cells (CTCs) are promising biomarkers for prognosis, therapeutic response
prediction, and treatment monitoring in cancer patients. Despite its epithelial origin, renal …

Rationale: We have a limited understanding of the molecular underpinnings of early
adenocarcinoma (ADC) progression. We hypothesized that the behavior of early ADC can …

Several diseases related to cell proliferation are characterized by the accumulation of
somatic DNA changes, with respect to wild-type conditions. Cancer and HIV are 2 common …

Objectives Radon, a natural radiation, is the leading environmental cause of lung cancer in
never-smokers. However, the radon exposure impact on the mutational landscape and …

Triple negative breast cancer (TNBC) is characterized by clinical aggressiveness, lack of
recognized target therapy, and a dismal patient prognosis. Several studies addressed …