Neuroimmune recognition and regulation in the respiratory system

J Chen, X Lai, Y Song, X Su - European Respiratory Review, 2024 - publications.ersnet.org
Neuroimmune recognition and regulation in the respiratory system is a complex and highly
coordinated process involving interactions between the nervous and immune systems to …

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins

A Aouacheria, S Baghdiguian, HM Lamb… - Neurochemistry …, 2017 - Elsevier
The morphology of a population of mitochondria is the result of several interacting dynamical
phenomena, including fission, fusion, movement, elimination and biogenesis. Each of these …

Impaired mitochondrial mobility in Charcot-Marie-Tooth disease

CR Schiavon, GS Shadel, U Manor - Frontiers in Cell and …, 2021 - frontiersin.org
Charcot-Marie-Tooth (CMT) disease is a progressive, peripheral neuropathy and the most
commonly inherited neurological disorder. Clinical manifestations of CMT mutations are …

Polarizing the neuron through sustained co-expression of alternatively spliced isoforms

K Yap, Y Xiao, BA Friedman, HS Je, EV Makeyev - Cell reports, 2016 - cell.com
Alternative splicing (AS) is an important source of proteome diversity in eukaryotes.
However, how this affects protein repertoires at a single-cell level remains an open question …

Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells

AM González-Jamett, X Baez-Matus, MJ Olivares… - Scientific Reports, 2017 - nature.com
Dynamin-2 is a ubiquitously expressed GTP-ase that mediates membrane remodeling.
Recent findings indicate that dynamin-2 also regulates actin dynamics. Mutations in …

How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells

AM Cárdenas, FD Marengo - Journal of Neurochemistry, 2016 - Wiley Online Library
The pattern of stimulation defines important characteristics of the secretory process in
neurons and neuroendocrine cells, including the pool of secretory vesicles being recruited …

How does the stimulus define exocytosis in adrenal chromaffin cells?

FD Marengo, AM Cárdenas - Pflügers Archiv-European Journal of …, 2018 - Springer
The extent and type of hormones and active peptides secreted by the chromaffin cells of the
adrenal medulla have to be adjusted to physiological requirements. The chromaffin cell …

The F-actin binding protein cortactin regulates the dynamics of the exocytotic fusion pore through its SH3 domain

AM González-Jamett, MJ Guerra… - Frontiers in Cellular …, 2017 - frontiersin.org
Upon cell stimulation, the network of cortical actin filaments is rearranged to facilitate the
neurosecretory process. This actin rearrangement includes both disruption of the preexisting …

Gain-of-Function Dynamin-2 Mutations Linked to Centronuclear Myopathy Impair Ca2+-Induced Exocytosis in Human Myoblasts

L Bayonés, MJ Guerra-Fernández… - International Journal of …, 2022 - mdpi.com
Gain-of-function mutations of dynamin-2, a mechano-GTPase that remodels membrane and
actin filaments, cause centronuclear myopathy (CNM), a congenital disease that mainly …

Dynamin superfamily at Pre-and postsynapses: Master regulators of synaptic transmission and plasticity in health and disease

J Arriagada-Diaz, L Prado-Vega… - The …, 2022 - journals.sagepub.com
Dynamin superfamily proteins (DSPs) comprise a large group of GTP-ases that orchestrate
membrane fusion and fission, and cytoskeleton remodeling in different cell-types. At the …