Since the original somatomedin hypothesis was conceived, a number of important
discoveries have allowed investigators to modify the concept. Originally somatic growth was …

Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-
releasing activity. This activity is mediated by the activation of the so-called GH …

Now a day's intranasal (in) drug delivery is emerging as a reliable method to bypass the
blood–brain barrier (BBB) and deliver a wide range of therapeutic agents including both …

Abstract Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to
reach the brain in a non-invasive way. This article is a comprehensive review of the state-of …

The secretion of growth hormone (GH) is regulated through a complex neuroendocrine
control system, especially by the functional interplay of two hypothalamic hypophysiotropic …

1. Introduction study nasal absorption of drugs. This area of drug delivery received
additional attention with a timely The most desirable and convenient method of drug seminar …

Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …

Uncovering the biological role of nuclear receptor peroxisome proliferator-activated
receptors (PPARs) has greatly advanced our knowledge of the transcriptional control of …

Peptidomimetic Regulation of Growth Hormone Secretion | Endocrine Reviews | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search …

An endogenous ligand for the GH secretagogue-receptor (GHS-R) has been recently
purified from rat and human stomach and named Ghrelin. It has been demonstrated that …