Mitotic chromosome assembly is an essential preparatory step for accurate transmission of
the genome during cell division. During the past decades, biochemical approaches have …

Cancers and neurodegenerative disorders are associated with both disrupted proteostasis
and altered nuclear morphology. Determining if changes in nuclear morphology contribute …

Chromatin undergoes a dramatic reorganization during the cell cycle–. In interphase,
chromatin is organized into compartments and topological-associating domains (TADs) that …

The nuclear pore complex (NPC) is the conduit in the nuclear envelope through which
proteins and RNA are transported between the cytoplasm and nucleus. Xenopus egg …

Experiments using cytoplasmic extracts prepared from Xenopus eggs have made important
contributions to our understanding of the cell cycle, the cytoskeleton, and cytoplasmic …

The ability to construct a functional system from its individual components is foundational to
understanding how it works. Synthetic biology is a broad field that draws from principles of …

Chromosome structure in both interphase and M-phase cells is strongly influenced by the
action of the cohesin and condensin protein complexes. The cohesin complex tethers the …

During cell division, chromosomes must be equally segregated to daughter cells.
Centromeres, the primary interaction site between chromosomes and microtubules, mediate …