Tumour heterogeneity poses a substantial problem for the clinical management of cancer.
Somatic evolution of the cancer genome results in genetically distinct subclones in the …

Abstract Objectives The Swedish Family-Cancer Database has been the major source of
population-based prospective data on familial risks on most cancers, including prostate …

Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in
developed countries and the second leading cause of cancer mortality, yet little is known …

The use of biomarkers for prostate cancer (PCa) screening, detection, and prognostication
have revolutionized the diagnosis and management of the disease. Current clinical practice …

Background There is an urgent need to identify factors specifically associated with
aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely …

BACKGROUND: Genetic factors seem to be of greater importance in prostate cancer than in
other forms of cancer. Studies have suggested familial concordance in survival, but the …

Abstract Background An important fraction (>/~ 10%) of men with high‐risk, localized
prostate cancer and metastatic prostate cancer carry germline (heritable) pathogenic and …

Background We addressed the hypothesis that individual-level factors act jointly with social
and built environment factors to influence overall survival for men with prostate cancer and …

CONTEXT: Despite widespread screening for prostate cancer (PCa) and major advances in
the treatment of metastatic disease, PCa remains the second most common cause of cancer …

Abstract The Swedish Family‐Cancer Database comprises a total of 11.8 million individuals
covering the Swedish population of the past 100 years. Version VIII of the Database is …