Organization and regulation of gene transcription
P Cramer - Nature, 2019 - nature.com
The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT
H Ehara, T Kujirai, M Shirouzu, H Kurumizaka… - Science, 2022 - science.org
During gene transcription, RNA polymerase II (RNAPII) traverses nucleosomes in chromatin,
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
Causes and consequences of RNA polymerase II stalling during transcript elongation
M Noe Gonzalez, D Blears, JQ Svejstrup - Nature reviews Molecular …, 2021 - nature.com
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
Challenges and opportunities in cryo-EM single-particle analysis
D Lyumkis - Journal of Biological Chemistry, 2019 - ASBMB
Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …
macromolecular objects and their assemblies. Although the techniques have been …
Nucleosome structure and dynamics are coming of age
Since the first high-resolution structure of the nucleosome was reported in 1997, the
available information on chromatin structure has increased very rapidly. Here, we review …
available information on chromatin structure has increased very rapidly. Here, we review …
Structural basis of nucleosome retention during transcription elongation
In eukaryotes, RNA polymerase (Pol) II transcribes chromatin and must move past
nucleosomes, often resulting in nucleosome displacement. How Pol II unwraps the DNA …
nucleosomes, often resulting in nucleosome displacement. How Pol II unwraps the DNA …
FACT caught in the act of manipulating the nucleosome
The organization of genomic DNA into nucleosomes profoundly affects all DNA-related
processes in eukaryotes. The histone chaperone known as 'facilitates chromatin …
processes in eukaryotes. The histone chaperone known as 'facilitates chromatin …
Structures of+ 1 nucleosome–bound PIC-Mediator complex
RNA polymerase II–mediated eukaryotic transcription starts with the assembly of the
preinitiation complex (PIC) on core promoters. The+ 1 nucleosome is well positioned about …
preinitiation complex (PIC) on core promoters. The+ 1 nucleosome is well positioned about …
[HTML][HTML] Structure of a backtracked hexasomal intermediate of nucleosome transcription
During gene transcription, RNA polymerase II (RNA Pol II) passes nucleosomes with the
help of various elongation factors. Here, we show that RNA Pol II achieves efficient …
help of various elongation factors. Here, we show that RNA Pol II achieves efficient …