Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated
successfully with surgery alone and survival rates are high, but after metastasis survival …

Cutaneous melanoma (CM) is one of the most rapidly growing cancers worldwide, with a
consistent increase in incidence among white populations over the past four decades …

Skin lesion segmentation has a critical role in the early and accurate diagnosis of skin
cancer by computerized systems. However, automatic segmentation of skin lesions in …

Mutations in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPDs),
DNA photoproducts that are typically created picoseconds after an ultraviolet (UV) photon is …

Melanoma is the most deadly of the common skin cancers and its incidence is rapidly
increasing. Approximately 10% of cases occur in a familial context. To date, cyclin …

So far, two genes associated with familial melanoma have been identified, accounting for a
minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of …

Abstract The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial
role in human and mouse pigmentation,,,,,,,. Activation of MC1R in melanocytes by α …

Nearly 15% of melanomas occur in patients with a family history and a subset of these
patients have a germline mutation in a melanoma predisposing gene. CDKN2A mutations …

Ultraviolet radiation (UVR) has numerous effects on skin, including DNA damage, tanning,
vitamin D synthesis, carcinogenesis, and immunomodulation. Keratinocytes containing …

Pigment production is a unique character of melanocytes. Numerous factors are linked with
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …