Applications of Raman spectroscopy in cancer diagnosis

GW Auner, SK Koya, C Huang, B Broadbent… - Cancer and Metastasis …, 2018 - Springer
Novel approaches toward understanding the evolution of disease can lead to the discovery
of biomarkers that will enable better management of disease progression and improve …

Vision 20/20: the role of Raman spectroscopy in early stage cancer detection and feasibility for application in radiation therapy response assessment

S Devpura, KN Barton, SL Brown, O Palyvoda… - Medical …, 2014 - Wiley Online Library
Raman spectroscopy is an optical technique capable of identifying chemical constituents of
a sample by their unique set of molecular vibrations. Research on the applicability of Raman …

Raman spectroscopy identifies radiation response in human non-small cell lung cancer xenografts

SJ Harder, M Isabelle, L DeVorkin, J Smazynski… - Scientific reports, 2016 - nature.com
External beam radiation therapy is a standard form of treatment for numerous cancers.
Despite this, there are no approved methods to account for patient specific radiation …

Raman spectroscopy and group and basis-restricted non negative matrix factorisation identifies radiation induced metabolic changes in human cancer cells

K Milligan, X Deng, P Shreeves, R Ali-Adeeb… - Scientific reports, 2021 - nature.com
This work combines single cell Raman spectroscopy (RS) with group and basis restricted
non-negative matrix factorisation (GBR-NMF) to identify individual biochemical changes …

A Raman spectroscopic study of cell response to clinical doses of ionizing radiation

SJ Harder, Q Matthews, M Isabelle… - Applied …, 2015 - journals.sagepub.com
The drive toward personalized radiation therapy (RT) has created significant interest in
determining patient-specific tumor and normal tissue responses to radiation. Raman …

Synergetic influence of bismuth oxide nanoparticles, cisplatin and baicalein-rich fraction on reactive oxygen species generation and radiosensitization effects for …

NN Talik Sisin, K Abdul Razak… - International Journal …, 2020 - Taylor & Francis
Purpose This study aimed to quantify synergetic effects induced by bismuth oxide
nanoparticles (BiONPs), cisplatin (Cis) and baicalein-rich fraction (BRF) natural-based agent …

Understanding radiation response and cell cycle variation in brain tumour cells using Raman spectroscopy

IE Hill, M Boyd, K Milligan, CA Jenkins, A Sorensen… - Analyst, 2023 - pubs.rsc.org
Radiation therapy is currently utilised in the treatment of approximately 50% of cancer
patients. A move towards patient tailored radiation therapy would help to improve the …

Radiation treatment response and hypoxia biomarkers revealed by machine learning assisted Raman spectroscopy in tumour cells and xenograft tissues

X Deng, K Milligan, A Brolo, JJ Lum, JL Andrews… - Analyst, 2022 - pubs.rsc.org
Recent advancements in anatomical imaging of tumours as treatment targets have led to
improvements in RT. However, it is unlikely that improved anatomical imaging alone will be …

Vibrational spectroscopy in sensing radiobiological effects: analyses of targeted and non-targeted effects in human keratinocytes

AD Meade, O Howe, V Unterreiner… - Faraday …, 2016 - pubs.rsc.org
Modern models of radiobiological effects include mechanisms of damage initiation, sensing
and repair, for those cells that directly absorb ionizing radiation as well as those that …

Group and basis restricted non-negative matrix factorization and random forest for molecular histotype classification and Raman biomarker monitoring in breast cancer

X Deng, K Milligan, R Ali-Adeeb… - Applied …, 2022 - journals.sagepub.com
Raman spectroscopy is a non-invasive optical technique that can be used to investigate
biochemical information embedded in cells and tissues exposed to ionizing radiation used …