Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

NLRP6 is important in host defense by inducing functional outcomes including
inflammasome activation and interferon production. Here, we show that NLRP6 undergoes …

Over the past decade, numerous advances have been made in the role and regulation of
inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Inflammation in the brain accompanies several high-impact neurological diseases including
multiple sclerosis (MS), stroke, and Alzheimer's disease. Neuroinflammation is sterile, as …

Summary 15 years ago, the fundamental biology of an inflammatory signaling complex
eventually dubbed “the inflammasome” began to unravel in chronologic parallel with the …

Inflammasomes are multimeric protein complexes that regulate inflammatory responses and
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …

Robust innate immune detection of rapidly evolving pathogens is critical for host defense.
Nucleotide-binding domain leucine-rich repeat (NLR) proteins function as cytosolic innate …

Nucleotide-binding domain leucine-rich repeat receptors (NLRs) play important roles in the
innate immune systems of both plants and animals. Recent breakthroughs in NLR …