Synapses enable neurons to communicate with each other and are therefore a prerequisite
for normal brain function. Presynaptically, this communication requires energy and …

Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …

Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

Mutations in the PSEN genes are the major cause of familial Alzheimer's disease, and
presenilin (PS) is the catalytic subunit of γ-secretase, which cleaves type I transmembrane …

Synaptic loss is the best correlate of cognitive deficits in Alzheimer's disease (AD). Extensive
experimental evidence also indicates alterations of synaptic properties at the early stages of …

Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the
maintenance of cellular homeostasis from the embryonic developmental stages to …

Rare mutations in the gene encoding presenilin2 (PSEN2) are known to cause familial
Alzheimer's disease (FAD). Here, we explored how altered PSEN2 expression impacts on …

Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial
Alzheimer's disease (FAD). It forms the catalytic core of the γ-secretase complex—a function …

Mutations in the Presenilin (PSEN1 and PSEN2) genes are the major cause of early-onset
familial Alzheimer's disease (FAD). Presenilin (PS) is the catalytic subunit of the γ-secretase …

The decrease of metabolism in the brain has been observed as the important lesions of
Alzheimer's disease (AD) from the early stages of diagnosis. The cumulative evidence has …