Simple Summary Multiple Myeloma (MM) is a hematologic malignancy caused by aberrant
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …

This review focuses on providing insights into the structural basis and clinical relevance of
LFA‐1 and VLA‐4 inhibition by peptides and small molecules as adhesion‐based …

EXPERIMENTAL autoimmune encephalomyelitis (EAE) is an inflammatory condition of the
central nervous system with similarities to multiple sclerosis1, 2. In both diseases, circulating …

The mucosal vascular addressin, MAdCAM-1, is an immunoglobulin superfamily adhesion
molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte …

Integrin-mediated adhesion influences cell survival and may prevent programmed cell
death. Little is known about how drug-sensitive tumor cell lines survive initial exposures to …

We generated vascular cell adhesion molecule (VCAM)-1 “knock-in” mice and Cre
recombinase transgenic mice to delete the VCAM-1 gene (vcam-1) in whole mice, thereby …

ENDOTHELIAL adhesion molecules facilitate the entry of leukocytes into inflamed tissues.
This in turn promotes neovascularization, a process central to the progression of rheumatoid …

Introduction 3. Discussion 3.1. Fibronectin 3.2. Integrins 3.3. Molecular mechanisms of
ligand-integrin interactions 3.4. Ligand specificity of fibronectin binding integrins 3.5 …

Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on
a powerful interplay between bone marrow stromal cells and MM cells that allows the latter …

Although integrins are known to be mechanosensitive and to possess many subtypes that
have distinct physiological roles, single molecule studies of force exertion have thus far …