Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …

The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …

The first report in literature of the isolation of coumarin was in the year 1820. After this report,
other papers were published demonstrating the isolation and synthesis of coumarin and …

Neurodegenerative disorders including Alzheimer's disease (AD) are drawing scientists'
attention within various fields, being one of the most serious diseases mankind will have to …

Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multi-faceted
pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized
by memory loss, cognitive impairment, and functional decline leading to dementia and …

Background: Acetylcholinesterase (AChE) is involved in the termination of impulse
transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous …

A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and
the antioxidant ebselen were designed as multi-target-directed ligands against Alzheimer's …

Metal-ion homeostasis in the brain is critical for many physiological functions, particularly in
the central nervous system where metals are essential in complex signaling pathways. Most …