The novel regulatory role of lnc RNA‐mi RNA‐mRNA axis in cardiovascular diseases

Y Huang - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Long noncoding RNA s (lnc RNA s) are RNA s longer than 200 nt in length that are
characterized by low levels of sequence conservation and expression; lnc RNA s modulate …

Pivotal role of TGF-β/Smad signaling in cardiac fibrosis: non-coding RNAs as effectual players

S Saadat, M Noureddini… - Frontiers in …, 2021 - frontiersin.org
Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions,
known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the …

[HTML][HTML] lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis

Y Yang, W Tai, N Lu, T Li, Y Liu, W Wu, Z Li, L Pu… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
Pulmonary fibrosis (PF) is a lethal fibrotic lung disease. The role of lncRNAs in multiple
diseases has been confirmed, but the role and mechanism of lncRNA zinc finger antisense 1 …

LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging

Z Yang, S Jiang, J Shang, Y Jiang, Y Dai, B Xu… - Ageing research …, 2019 - Elsevier
Fibrosis is universally observed in multiple aging-related diseases and progressions and is
characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various …

Non-coding RNA-based regulation of inflammation

M Ashrafizadeh, A Zarrabi, E Mostafavi, AR Aref… - Seminars in …, 2022 - Elsevier
Inflammation is a multifactorial process and various biological mechanisms and pathways
participate in its development. The presence of inflammation is involved in pathogenesis of …

N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by …

B Han, C Chu, X Su, N Zhang, L Zhou, M Zhang… - …, 2020 - Taylor & Francis
The pulmonary fibrosis could be caused by long-term inhalation of carbon black (CB)
particles. Studies on the mechanisms of pulmonary fibrosis induced by CB are required to …

[HTML][HTML] Non-coding RNAs modulate function of extracellular matrix proteins

NA Dilmaghnai, H Shoorei, G Sharifi, M Mohaqiq… - Biomedicine & …, 2021 - Elsevier
The extracellular matrix (ECM) creates a multifaceted system for the interaction of diverse
structural proteins, matricellular molecules, proteoglycans, hyaluronan, and various …

MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1

W Yan, Q Wu, W Yao, Y Li, Y Liu, J Yuan, R Han… - Scientific Reports, 2017 - nature.com
Silicosis is a kind of chronic, progressive and incurable lung fibrotic diseases with largely
unknown and complex pathogenesis and molecular mechanisms. Mounting evidence …

Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence

MDA Paskeh, S Mirzaei, S Orouei, A Zabolian… - International Journal of …, 2021 - Elsevier
Recently, microRNAs (miRNAs) have shown to be potential therapeutic, diagnostic and
prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to …

Role of microRNAs in TGF-β signaling pathway-mediated pulmonary fibrosis

H Kang - International journal of molecular sciences, 2017 - mdpi.com
Pulmonary fibrosis is the most common form of interstitial lung disease. The transforming
growth factor-β (TGF-β) signaling pathway is extensively involved in the development of …