The age-associated decline of the neurological and cognitive functions becomes more and
more serious challenge for the developed countries with the increasing number of aged …

The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

The blood–brain barrier (BBB) plays a crucial role in maintaining the specialized
microenvironment of the central nervous system (CNS). In aging, the stability of the BBB …

Alzheimer's disease (AD) is the most common cause of dementia and one of the most
important causes of morbidity and mortality among the aging population. AD diagnosis is …

Cerebral microvascular rarefaction, the reduction in number of functional or structural small
blood vessels in the brain, is thought to play an important role in the early stages of …

The blood-brain barrier (BBB) is the interface between the blood and brain tissue, which
regulates the maintenance of homeostasis within the brain. Impaired BBB integrity is …

The definition of Alzheimer's disease (AD) now considers the presence of the markers of
amyloid (A), tau deposition (T), and neurodegeneration (N) essential for diagnosis. AD …

Medications for type 2 diabetes (T2DM) offer a promising path for discovery and
development of effective interventions for dementia syndromes. A common feature of …

Background: Blood-brain barrier (BBB) dysfunction could favor the pathogenesis and
progression of Alzheimer's disease (AD). Vascular risk factors (VRF) could worsen BBB …

An important worldwide health problem as the result of current lifestyle is metabolic
syndrome (MS). It has been shown that MS induced by a high‐calorie diet (HCD) in rats …