RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

The syndrome of monocytopenia, B-cell and NK-cell lymphopenia, and mycobacterial,
fungal, and viral infections is associated with myelodysplasia, cytogenetic abnormalities …

▪ Abstract Human leukemias are typified by acquired recurring chromosomal translocations.
Cloning of these translocation breakpoints has provided important insights into …

Children with Down syndrome have a 10–20-fold elevated risk of developing leukemia,
particularly acute megakaryoblastic leukemia (AMKL) 1. While a subset of pediatric AMKLs …

Recently our group and others have identified DDX41 mutations both as germ line and
acquired somatic mutations in families with multiple cases of late onset myelodysplastic …

Although much is understood about the ways in which transcription factors regulate various
differentiation systems, and one of the hallmarks of many human cancers is a lack of cellular …

Purpose To determine the association of RUNX1 mutations with therapeutic outcome in
younger and older patients with primary cytogenetically normal acute myeloid leukemia (CN …

Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …