Reactive oxygen species (ROS) initially considered as only damaging agents in living
organisms further were found to play positive roles also. This paper describes ROS …

The presence of reactive oxygen species (ROS) in living organisms was described more
than 60 years ago and virtually immediately it was suggested that ROS were involved in …

Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine
to xanthine and xanthine to uric acid and is widely distributed among species. In addition to …

Chemotherapy is currently one of the most effective ways to treat metastatic cancers.
However, of the various mechanisms that are involved in conferring resistance, upregulation …

Mitochondria dysfunction and hypoxic microenvironment are hallmarks of cancer cell
biology. Recently, many studies have focused on isolation of brain cancer stem cells using …

Temozolomide (TMZ) is an oral alkylating agent used for the treatment of high-grade
gliomas. Acquired chemoresistance is a severe limitation to this therapy with more than 90 …

Human xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism
and is present in two interconvertible forms, which may utilize O2 or NAD+ as electron …

This study is the first to investigate the anticancer effect of plumbagin in human melanoma
A375. S2 cells. Plumbagin exhibited effective cell growth inhibition by inducing cancer cells …

Background Environment inside even a small tumor is characterized by total (anoxia) or
partial oxygen deprivation,(hypoxia). It has been shown that radiotherapy and some …

Temozolomide (TMZ) is an alkylating agent used for treating gliomas. Chemoresistance is a
severe limitation to TMZ therapy; there is a critical need to understand the underlying …