Immunological considerations for COVID-19 vaccine strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
Macrophage: a cell with many faces and functions in tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections
The innate immune system is able to build memory-like features in response to certain
infections or vaccines, resulting in enhanced responsiveness upon (re) challenge with the …
infections or vaccines, resulting in enhanced responsiveness upon (re) challenge with the …
Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis
A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) that we refer to as
'resisters'(RSTR) show evidence of IFN-γ− T cell responses to Mtb-specific antigens despite …
'resisters'(RSTR) show evidence of IFN-γ− T cell responses to Mtb-specific antigens despite …
Targeting innate immunity for tuberculosis vaccination
Vaccine development against tuberculosis (TB) is based on the induction of adaptive
immune responses endowed with long-term memory against mycobacterial antigens …
immune responses endowed with long-term memory against mycobacterial antigens …
Key advances in vaccine development for tuberculosis—Success and challenges
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …
vaccines have galvanized the field and suggest, for the first time since the development of …
Accelerating research and development of new vaccines against tuberculosis: a global roadmap
F Cobelens, RK Suri, M Helinski… - The Lancet Infectious …, 2022 - thelancet.com
To eliminate tuberculosis globally, a new, effective, and affordable vaccine is urgently
needed, particularly for use in adults and adolescents in low-income and middle-income …
needed, particularly for use in adults and adolescents in low-income and middle-income …
Clinical manifestations and immune response to tuberculosis
ML Carabalí-Isajar, OH Rodríguez-Bejarano… - World Journal of …, 2023 - Springer
Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …
A century of BCG: Impact on tuberculosis control and beyond
BCG turns 100 this year and while it might not be the perfect vaccine, it has certainly
contributed significantly towards eradication and prevention of spread of tuberculosis (TB) …
contributed significantly towards eradication and prevention of spread of tuberculosis (TB) …
Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination
MPM Vierboom, K Dijkman, CC Sombroek… - Cell Reports …, 2021 - cell.com
BCG vaccination can strengthen protection against pathogens through the induction of
epigenetic and metabolic reprogramming of innate immune cells, a process called trained …
epigenetic and metabolic reprogramming of innate immune cells, a process called trained …