Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Rationale: Endothelial dysfunction is an important determinant risk factor for the
development of hypertension and its complications. Thus, identification of potential …

Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …

SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases
and has established diverse roles in aging, metabolism and disease. Its function is similar to …

Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+)-dependent histone deacetylase that
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …

Pathological cardiac hypertrophy involves excessive protein synthesis, increased cardiac
myocyte size and ultimately the development of heart failure. Thus, pathological cardiac …

Abstract Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD+-dependent deacetylases
with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its …