IgA antibodies and IgA deficiency in SARS-CoV-2 infection

I Quinti, EP Mortari, A Fernandez Salinas… - Frontiers in Cellular …, 2021 - frontiersin.org
A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent
mechanisms useful in defense against pathogenic microorganisms and to reduce immune …

COVID-19 biomarkers and advanced sensing technologies for point-of-care (POC) diagnosis

EE Etienne, BB Nunna, N Talukder, Y Wang, ES Lee - Bioengineering, 2021 - mdpi.com
COVID-19, also known as SARS-CoV-2 is a novel, respiratory virus currently plaguing
humanity. Genetically, at its core, it is a single-strand positive-sense RNA virus. It is a beta …

Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

L Renia, YS Goh, A Rouers, N Le Bert, WN Chia… - Nature …, 2022 - nature.com
Understanding the impact of age on vaccinations is essential for the design and delivery of
vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of …

Relative ratios of human seasonal coronavirus antibodies predict the efficiency of cross-neutralization of SARS-CoV-2 spike binding to ACE2

Y Galipeau, V Siragam, G Laroche, E Marion… - …, 2021 - thelancet.com
Background Antibodies raised against human seasonal coronaviruses (sCoVs), which are
responsible for the common cold, are known to cross-react with SARS-CoV-2 antigens. This …

IgG3 and IgM identified as key to SARS-CoV-2 neutralization in convalescent plasma pools

C Kober, S Manni, S Wolff, T Barnes, S Mukherjee… - PLoS …, 2022 - journals.plos.org
Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most
important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed …

Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection

MZ Tay, A Rouers, SW Fong, YS Goh… - EMBO molecular …, 2022 - embopress.org
Abstract The SARS‐CoV‐2 Delta (B. 1.617. 2) variant is capable of infecting vaccinated
persons. An open question remains as to whether deficiencies in specific vaccine‐elicited …

Waning of specific antibodies against Delta and Omicron variants five months after a third dose of BNT162b2 SARS-CoV-2 vaccine in elderly individuals

YS Goh, A Rouers, SW Fong, NZ Zhuo, PX Hor… - Frontiers in …, 2022 - frontiersin.org
The emergence of new SARS-CoV-2 variants, such as the more transmissible Delta and
Omicron variants, has raised concerns on efficacy of the COVID-19 vaccines. Here, we …

Persistent maintenance of intermediate memory B cells following SARS-CoV-2 infection and vaccination recall response

J Pušnik, J König, K Mai, E Richter, J Zorn… - Journal of …, 2022 - Am Soc Microbiol
Robust population-wide immunity will help to curb the SARS-CoV-2 pandemics. To maintain
the immunity at protective levels, the quality and persistence of the immune response …

Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months

J Serwanga, V Ankunda, J Sembera, L Kato… - Frontiers in …, 2023 - frontiersin.org
Introduction Understanding how spike (S)-, nucleoprotein (N)-, and RBD-directed antibody
responses evolved in mild and asymptomatic COVID-19 in Africa and their interactions with …

Memory B cells and serum immunoglobulins are associated with disease severity and mortality in patients with COVID-19

F Çölkesen, EK Kurt, H Vatansev… - Postgraduate …, 2022 - academic.oup.com
Purpose of the study The aim of this study was to investigate the relationship of B cell-
mediated immunity with disease severity and mortality in patients with COVID-19. Study …