Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …
programming and gene regulation during development as well as in health and …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Exosome mimetics: a novel class of drug delivery systems
SAA Kooijmans, P Vader… - International journal …, 2012 - Taylor & Francis
The identification of extracellular phospholipid vesicles as conveyors of cellular information
has created excitement in the field of drug delivery. Biological therapeutics, including short …
has created excitement in the field of drug delivery. Biological therapeutics, including short …
miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir
S Thakral, K Ghoshal - Current gene therapy, 2015 - ingentaconnect.com
miR-122, a completely conserved liver-specific miRNA in vertebrates, is essential for the
maintenance of liver homeostasis. This 22 nucleotide RNA regulates diverse functions such …
maintenance of liver homeostasis. This 22 nucleotide RNA regulates diverse functions such …
MicroRNA-223 is neuroprotective by targeting glutamate receptors
Stroke is a major cause of mortality and morbidity worldwide. Extracellular glutamate
accumulation leading to overstimulation of the ionotropic glutamate receptors mediates …
accumulation leading to overstimulation of the ionotropic glutamate receptors mediates …
Alterations in cardiac DNA methylation in human dilated cardiomyopathy
Dilated cardiomyopathies (DCM) show remarkable variability in their age of onset,
phenotypic presentation, and clinical course. Hence, disease mechanisms must exist that …
phenotypic presentation, and clinical course. Hence, disease mechanisms must exist that …
Metabolism and epigenetic interplay in cancer: regulation and putative therapeutic targets
V Miranda-Gonçalves, A Lameirinhas… - Frontiers in …, 2018 - frontiersin.org
Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells
facilitating cancer development and progression. Modulation of histone and DNA …
facilitating cancer development and progression. Modulation of histone and DNA …
Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma
G Cabrini, E Fabbri, CL Nigro… - International …, 2015 - spandidos-publications.com
O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed nuclear
protein dealkylating O6-methylguanine (O6-MG) DNA residue, thus correcting the …
protein dealkylating O6-methylguanine (O6-MG) DNA residue, thus correcting the …
[HTML][HTML] From microRNA functions to microRNA therapeutics: novel targets and novel drugs in breast cancer research and treatment
R Piva, DA Spandidos… - … journal of oncology, 2013 - spandidos-publications.com
MicroRNAs (miRNAs or miRs) are a family of small non‑coding RNAs that regulate gene
expression by the sequence-selective targeting of mRNAs, leading to translational …
expression by the sequence-selective targeting of mRNAs, leading to translational …
[HTML][HTML] Focus: genome editing: therapeutic peptide nucleic acids: principles, limitations, and opportunities
Since their invention in 1991, peptide nucleic acids (PNAs) have been used in a myriad of
chemical and biological assays. More recently, peptide nucleic acids have also been …
chemical and biological assays. More recently, peptide nucleic acids have also been …