Recent interest in the role of serotonin (5-HT) in antipsychotic drug action is based mainly
upon the fact that antipsychotic drugs such as clozapine, olanzapine, quetiapine …

Serotonin (5-hydroxytryptamine, 5-HT), the “happy hormone,” has a phylogenetically ancient
role in neural transmission (Turlejski, 1996). Because the serotonergic system has a …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Page 1 Supplement to THE AMERICAN JOURNAL OF PSYCHIATRY Official Journal of the
AMERICAN PSYCHIATRIC ASSOCIATION Volume 159 Number 4 April 2002 PRACTICE for the …

OBJECTIVE: The primary intent of this study was to compare the efficacy and safety of
olanzapine and placebo in the treatment of acute mania. METHOD: The design involved a …

These updated guidelines are based on a first edition that was published in 2003, and have
been edited and updated with the available scientific evidence until end of 2008. Their …

Background: Although symptoms of anxiety as well as anxiety disorders commonly occur in
patients with bipolar disorder, the pathophysiologic, theoretical, and clinical significance of …

Since the previous publication of Canadian Network for Mood and Anxiety Treatments
(CANMAT) guidelines in 1997, there has been a substantial increase in evidence‐based …

TIONS antipsychotic is sometimes necessary [II]. Severely ill or agitated patients may also
require short-term adjunctive treatment with a benzodiazepine [I]. When first-line medication …

Objective To evaluate the efficacy and safety of clozapine for treatment‐resistant bipolar
disorder (TRBD). Methods A systematic review of randomized controlled studies, open‐label …