Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …

Morphinan-based painkillers are derived from opium poppy (Papaver somniferum L.). We
report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 …

Plant natural products are of great value for agriculture, medicine and a wide range of other
industrial applications. The discovery of new plant natural product pathways is currently …

Proteins found in nature have traditionally been the most frequently used biocatalysts to
produce numerous natural products ranging from commodity chemicals to pharmaceuticals …

Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …

Opioids are the primary drugs used in Western medicine for pain management and palliative
care. Farming of opium poppies remains the sole source of these essential medicines …

Highlights•Imine reductases (IREDs) enable the asymmetric synthesis of amines from
imines.•The development of annotated sequence databases has led to the discovery of new …

For millions of years, plants evolve plenty of structurally diverse secondary metabolites (SM)
to support their sessile lifestyles through continuous biochemical pathway innovation. While …

L-Tyrosine (Tyr) is an aromatic amino acid (AAA) required for protein synthesis in all
organisms, but synthesized de novo only in plants and microorganisms. In plants, Tyr also …