Efficacy of mesenchymal stromal cell therapy for acute lung injury in preclinical animal models: a systematic review

LA McIntyre, D Moher, DA Fergusson, KJ Sullivan… - PloS one, 2016 - journals.plos.org
The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical condition that is
associated with a 30–40% risk of death, and significant long term morbidity for those who …

Immunomodulation of mesenchymal stem cells in acute lung injury: from preclinical animal models to treatment of severe COVID-19

JP Li, KH Wu, WR Chao, YJ Lee, SF Yang… - International Journal of …, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has been a major public health challenge …

Mesenchymal stem cells from bone marrow, adipose tissue, and lung tissue differentially mitigate lung and distal organ damage in experimental acute respiratory …

JD Silva, M Lopes-Pacheco, AHR Paz… - Critical care …, 2018 - journals.lww.com
Objectives: Mesenchymal stem cells–based therapies have shown promising effects in
experimental acute respiratory distress syndrome. Different mesenchymal stem cells …

Concise review: the obesity cancer paradigm: exploration of the interactions and crosstalk with adipose stem cells

AL Strong, ME Burow, JM Gimble, BA Bunnell - Stem cells, 2015 - academic.oup.com
With the recognition of obesity as a global health crisis, researchers have devoted greater
effort to defining and understanding the pathophysiological molecular pathways regulating …

Human mesenchymal stem cells overexpressing the IL-33 antagonist soluble IL-1 receptor–like–1 attenuate endotoxin-induced acute lung injury

I Martínez-González, O Roca, JR Masclans… - American journal of …, 2013 - atsjournals.org
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by
pulmonary edema attributable to alveolar epithelial–interstitial–endothelial injury …

Human adipose stromal/stem cells from obese donors show reduced efficacy in halting disease progression in the experimental autoimmune encephalomyelitis model …

AL Strong, AC Bowles, RM Wise, JP Morand… - Stem Cells, 2016 - academic.oup.com
Multiple sclerosis is an autoimmune disease that affects the white matter of the central
nervous system and involves inflammation and demyelination. The recent advances in our …

Adipose-derived mesenchymal stromal cells modulate lipid metabolism and lipid droplet biogenesis via AKT/mTOR–PPARγ signalling in macrophages

L Souza-Moreira, VC Soares, SSG Dias, PT Bozza - Scientific reports, 2019 - nature.com
Mesenchymal stromal cells (MSCs) are a potential therapy for many chronic inflammatory
diseases due to their regenerative, immunologic and anti-inflammatory properties. The two …

Therapeutic potential of adipose stem cells

RA Sabol, AC Bowles, A Côté, R Wise… - Cell Biology and …, 2018 - Springer
Adipose stem cells (ASCs) have gained attention in the fields of stem cells regenerative
medicine due to their multifaceted therapeutic capabilities. Promising preclinical evidence of …

Reactive oxygen species in mesenchymal stem cell aging: implication to lung diseases

SR Yang, JR Park, KS Kang - Oxidative medicine and cellular …, 2015 - Wiley Online Library
MSCs have become an emerging cell source with their immune modulation, high
proliferation rate, and differentiation potential; indeed, they have been challenged in clinical …

[HTML][HTML] Stem cell therapy in COVID-19: Pooled evidence from SARS-CoV-2, SARS-CoV, MERS-CoV and ARDS: A systematic review

S Mahendiratta, S Bansal, P Sarma, H Kumar… - Biomedicine & …, 2021 - Elsevier
Abstract Background SARS-CoV-2, which majorly affects the lungs and respiratory tract is
thought due to dysregulation of the immune system which causes an immense imbalance of …