The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

Endometriosis is a condition that is influenced by hormones and involves stroma and glands
being found outside the uterus; there are increases in proliferation, invasion, internal …

Epithelial‐mesenchymal transition (EMT) is involved in physiologic processes such as
embryogenesis and wound healing. A similar mechanism occurs in some tumors where …

Metastatic melanoma is the most aggressive and difficult to treat type of skin cancer, with a
survival rate of less than 10%. Metastatic melanoma has conventionally been considered …

For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been
recognized as a key component in cancer progression. Initially, the primary roles assigned …

Abstract Interleukin 17A (IL-17A) is a major member of the IL-17 cytokine family and is
produced mainly by T helper 17 (Th17) cells. Other cells such as CD8+ T cells, γδ T cells …

Metastasis is currently the leading cause of cancer related death and is the most feared and
difficult to treat outcome for cancer patients. This complex process is regulated by a plethora …