Molecular mechanisms and physiological functions of mitophagy

M Onishi, K Yamano, M Sato, N Matsuda… - The EMBO …, 2021 - embopress.org
Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Mitochondrial dysfunction and mitophagy in Parkinson's disease: from mechanism to therapy

AB Malpartida, M Williamson, DP Narendra… - Trends in biochemical …, 2021 - cell.com
Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

[HTML][HTML] Selective autophagy of intracellular organelles: recent research advances

W Li, P He, Y Huang, YF Li, J Lu, M Li, H Kurihara… - Theranostics, 2021 - ncbi.nlm.nih.gov
Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Mitochondrial DNA in inflammation and immunity

JS Riley, SWG Tait - EMBO reports, 2020 - embopress.org
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

MF Schmidt, ZY Gan, D Komander… - Cell Death & …, 2021 - nature.com
Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Mitochondrial dynamics and its involvement in disease

DC Chan - Annual review of pathology: mechanisms of disease, 2020 - annualreviews.org
The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …

[HTML][HTML] Mitochondrial degradation: Mitophagy and beyond

L Uoselis, TN Nguyen, M Lazarou - Molecular cell, 2023 - cell.com
Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

[HTML][HTML] Quality control of the mitochondrion

MYW Ng, T Wai, A Simonsen - Developmental cell, 2021 - cell.com
Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

PINK1/Parkin-mediated mitophagy in neurodegenerative diseases

J Li, D Yang, Z Li, M Zhao, D Wang, Z Sun, P Wen… - Ageing research …, 2023 - Elsevier
Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

Activation mechanism of PINK1

ZY Gan, S Callegari, SA Cobbold, TR Cotton… - Nature, 2022 - nature.com
Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal
recessive early onset Parkinson's disease,. PINK1 has many unique features that enable it …