STAT proteins in cancer: orchestration of metabolism

YJ Li, C Zhang, A Martincuks, A Herrmann… - Nature reviews Cancer, 2023 - nature.com
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Influence of diet and nutrition on prostate cancer

M Matsushita, K Fujita, N Nonomura - International journal of molecular …, 2020 - mdpi.com
The incidence of prostate cancer (PCa) displays widespread regional differences, probably
owing to differences in dietary habits. Nutrients, including fat, protein, carbohydrates …

Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression

Q Zhang, X Yang, J Wu, S Ye, J Gong, WM Cheng… - Cell discovery, 2023 - nature.com
Metabolic reprogramming is a hallmark of cancer. However, it is not well known how
metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA …

Microbiome and prostate cancer: a novel target for prevention and treatment

N Kustrimovic, R Bombelli, D Baci… - International Journal of …, 2023 - mdpi.com
Growing evidence of the microbiome's role in human health and disease has emerged since
the creation of the Human Microbiome Project. Recent studies suggest that alterations in …

Pentadecanoic acid, an odd-chain fatty acid, suppresses the stemness of MCF-7/SC human breast cancer stem-like cells through JAK2/STAT3 signaling

NB To, YTK Nguyen, JY Moon, MK Ediriweera, SK Cho - Nutrients, 2020 - mdpi.com
Saturated fatty acids possess few health benefits compared to unsaturated fatty acids.
However, increasing experimental evidence demonstrates the nutritionally beneficial role of …

Influence of the bioactive diet components on the gene expression regulation

J Mierziak, K Kostyn, A Boba, M Czemplik, A Kulma… - Nutrients, 2021 - mdpi.com
Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food
constituents, which can transfer information from the external environment and influence …

Targeting lipid metabolism in metastatic prostate cancer

T Scheinberg, B Mak, L Butler… - … Advances in Medical …, 2023 - journals.sagepub.com
Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have
de novo resistance, and all will develop resistance to current therapeutics over time …

Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death

KK Frietze, AM Brown, D Das, RG Franks… - Autophagy, 2022 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease
globally. NAFLD is a consequence of fat accumulation in the liver leading to lipotoxicity …

STAT3 and Its Pathways' Dysregulation—Underestimated Role in Urological Tumors

M Golus, P Bugajski, J Chorbińska, W Krajewski… - Cells, 2022 - mdpi.com
Nowadays, molecular research is essential for the better understanding of tumor cells'
pathophysiology. The increasing number of neoplasms is taken under 'the molecular …

[HTML][HTML] STAT3 signaling in prostate cancer progression and therapy resistance: An oncogenic pathway with diverse functions

M Sadrkhanloo, MDA Paskeh, M Hashemi… - Biomedicine & …, 2023 - Elsevier
The categorization of cancers demonstrates that prostate cancer is the most common
malignancy in men and it causes high death annually. Prostate cancer patients are …