Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Kainate receptor antagonists: recent advances and therapeutic perspective
P Chałupnik, E Szymańska - International Journal of Molecular Sciences, 2023 - mdpi.com
Since the 1990s, ionotropic glutamate receptors have served as an outstanding target for
drug discovery research aimed at the discovery of new neurotherapeutic agents. With the …
drug discovery research aimed at the discovery of new neurotherapeutic agents. With the …
Functional insights from glutamate receptor ion channel structures
X-ray crystal structures for the soluble amino-terminal and ligand-binding domains of
glutamate receptor ion channels, combined with a 3.6-Å-resolution structure of the full-length …
glutamate receptor ion channels, combined with a 3.6-Å-resolution structure of the full-length …
The hidden energetics of ligand-binding and activation in a glutamate receptor
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory synaptic transmission in the central nervous system. The free energy of …
majority of excitatory synaptic transmission in the central nervous system. The free energy of …
Lessons from crystal structures of kainate receptors
S Møllerud, K Frydenvang, DS Pickering, JS Kastrup - Neuropharmacology, 2017 - Elsevier
Kainate receptors belong to the family of ionotropic glutamate receptors. These receptors
assemble from five subunits (GluK1-5) into tetrameric ion channels. Kainate receptors are …
assemble from five subunits (GluK1-5) into tetrameric ion channels. Kainate receptors are …
Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation
ML Mayer - Current opinion in neurobiology, 2011 - Elsevier
Ionotropic glutamate receptors (iGluRs) are ligand gated ion channels that mediate
excitatory synaptic transmission in the brain of vertebrates. A rapidly growing body of crystal …
excitatory synaptic transmission in the brain of vertebrates. A rapidly growing body of crystal …
Pharmacology of ionotropic glutamate receptors: A structural perspective
P Stawski, H Janovjak, D Trauner - Bioorganic & medicinal chemistry, 2010 - Elsevier
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Recent progress in neuroactive marine natural products
R Sakai, GT Swanson - Natural product reports, 2014 - pubs.rsc.org
Covering: 1995 to early 2013 This review covers the isolation, chemical structure, biological
activity, structure activity relationships including synthesis of chemical probes, and …
activity, structure activity relationships including synthesis of chemical probes, and …
Selective effect of cell membrane on synaptic neurotransmission
PA Postila, I Vattulainen, T Róg - Scientific reports, 2016 - nature.com
Atomistic molecular dynamics simulations were performed with 13 non-peptidic
neurotransmitters (NTs) in three different membrane environments. The results provide …
neurotransmitters (NTs) in three different membrane environments. The results provide …