Low and oscillatory wall shear stress is widely assumed to play a key role in the initiation
and development of atherosclerosis. Indeed, some studies have relied on the low shear …

This review places modern research developments in vascular mechanobiology in the
context of hemodynamic phenomena in the cardiovascular system and the discrete …

The shape of the arterial pulse wave is intimately related to the physical properties of the
cardiovascular system. Understanding the mechanisms underlying this relation is clinically …

Vascularization remains a long-standing challenge in engineering complex tissues.
Particularly needed is recapitulating 3D vascular features, including continuous geometries …

A striking feature of atherosclerosis is its patchy distribution within the vascular system;
certain arteries and certain locations within each artery are preferentially affected. Identifying …

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of
the aorta, which plays a critical role in the maintenance of aortic wall integrity. VSMCs have …

Background and Purpose Reduced NO levels and activity are signs of endothelial
dysfunction, which is important in mediating BP changes. Previously, we demonstrated that …

Since the first observation of a helical flow pattern in aortic blood flow, the existence of
helical blood flow has been found to be associated with various pathological conditions …

The aorta, with ascending, arch, thoracic and abdominal segments, responds to the
heartbeat, senses metabolites and distributes blood to all parts of the body. However, the …

Background The presence of calcified atherosclerosis in different vascular beds has been
associated with a higher risk of mortality. Thoracic aorta calcium (TAC) can be assessed …