The mechanisms of action of the rapid antidepressant effects of ketamine, an N-methyl-D-
aspartate glutamate receptor antagonist, have not been fully elucidated. This study …

Background Several lines of evidence implicate abnormal serotonergic function in suicidal
behavior and completed suicide, including low serotonin transporter binding in postmortem …

Background At subanesthetic doses, ketamine, an N-methyl-D-aspartate glutamate receptor
antagonist, increases glutamate release. We imaged the acute effect of ketamine on brain …

BACKGROUND: Chronic selective serotonin reuptake inhibitor (SSRI) administration to
rodents desensitizes or downregulates raphe 5-hydroxytryptamine 1A (5-HT1A) …

The serotonin (5-hydroxytryptamine, or 5-HT) type 1A receptor (5-HT1AR) is implicated in
the pathophysiology of numerous neuropsychiatric disorders. We have published the initial …

Background We previously reported higher serotonin 1A receptor (5-HT1A) binding in
subjects with major depressive disorder (MDD) during a major depressive episode using …

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in the
pathophysiology of mood and anxiety disorders. Recently, a positron emission tomography …

Background Abnormalities in the hypothalamic-pituitary-adrenal axis, serotonergic system,
and stress response have been linked to the pathogenesis of major depressive disorder …

We examined relationships between the serotonin system and stress in major depression
and suicidal behavior. Twenty-five medication-free depressed participants (13 suicide …

Abstract Background The serotonin 1A (5-HT1A) receptor has been implicated in depression
and suicidal behavior. Lower resting cortisol levels are associated with higher 5-HT1A …