Diversity of P450 enzymes in the biosynthesis of natural products

LM Podust, DH Sherman - Natural product reports, 2012 - pubs.rsc.org
Covering: 1985 to 2012 Diverse oxygenation patterns of natural products generated by
secondary metabolic pathways in microorganisms and plants are largely achieved through …

Advances and prospects of phenolic acids production, biorefinery and analysis

E Valanciene, I Jonuskiene, M Syrpas, E Augustiniene… - Biomolecules, 2020 - mdpi.com
Biotechnological production of phenolic acids is attracting increased interest due to their
superior antioxidant activity, as well as other antimicrobial, dietary, and health benefits. As …

[HTML][HTML] P450Rdb: a manually curated database of reactions catalyzed by cytochrome P450 enzymes

Y Zhang, X Pan, T Shi, Z Gu, Z Yang, M Liu, Y Xu… - Journal of Advanced …, 2024 - Elsevier
Abstract Introduction Cytochrome P450 enzymes (P450s) are recognized as the most
versatile catalysts worldwide, playing vital roles in numerous biological metabolism and …

Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex

Y Lin, Y Yan - Microbial cell factories, 2012 - Springer
Abstract Background Caffeic acid (3, 4-dihydroxycinnamic acid) is a natural phenolic
compound derived from the plant phenylpropanoid pathway. Caffeic acid and its phenethyl …

Synthesis of chemicals by metabolic engineering of microbes

X Sun, X Shen, R Jain, Y Lin, J Wang, J Sun… - Chemical society …, 2015 - pubs.rsc.org
Metabolic engineering is a powerful tool for the sustainable production of chemicals. Over
the years, the exploration of microbial, animal and plant metabolism has generated a wealth …

Mimicking a natural pathway for de novo biosynthesis: natural vanillin production from accessible carbon sources

J Ni, F Tao, H Du, P Xu - Scientific reports, 2015 - nature.com
Plant secondary metabolites have been attracting people's attention for centuries, due to
their potentials; however, their production is still difficult and costly. The rich diversity of …

Pharmaceutical removal from wastewater by introducing cytochrome P450s into microalgae

T Kariyawasam, C Helvig, M Petkovich… - Microbial …, 2024 - Wiley Online Library
Pharmaceuticals are of increasing environmental concern as they emerge and accumulate
in surface‐and groundwater systems around the world, endangering the overall health of …

Artificial biosynthesis of phenylpropanoic acids in a tyrosine overproducing Escherichia coli strain

SY Kang, O Choi, JK Lee, BY Hwang, TB Uhm… - Microbial cell …, 2012 - Springer
Background The phenylpropanoid metabolites are an extremely diverse group of natural
products biosynthesized by plants, fungi, and bacteria. Although these compounds are …

Caffeic acid production from glucose using metabolically engineered Escherichia coli

K Sakae, D Nonaka, M Kishida, Y Hirata… - Enzyme and Microbial …, 2023 - Elsevier
Abstract Caffeic acid (3, 4-dihydroxycinnamic acid) is a precursor for high-valued
compounds with anticancer, antiviral activities, and anti-inflammatory making it an important …

Heterologous production of curcuminoids

JL Rodrigues, KLJ Prather, LD Kluskens… - Microbiology and …, 2015 - Am Soc Microbiol
Curcuminoids, components of the rhizome of turmeric, show several beneficial biological
activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities …