Our ability to assess the threat posed by the genetic load to small and declining populations
has been greatly improved by advances in genome sequencing and computational …

Members of the genus Brucella are pathogenic bacteria exceedingly well adapted to their
hosts. The bacterium is transmitted by direct contact within the same host species or …

Effective population size is fundamental in population genetics and characterizes genetic
diversity. To infer past population dynamics from molecular sequence data, coalescent …

Continental-scale estimates of vegetation cover, including land-surface properties and
biogeographic trends, reflect the response of plant species to climate change over the past …

Estimation of demographic history from nucleotide sequences represents an important
component of many studies in molecular ecology. For example, knowledge of a population's …

Despite decades of research, the roles of climate and humans in driving the dramatic
extinctions of large-bodied mammals during the Late Quaternary period remain contentious …

Many coalescent-based methods aiming to infer the demographic history of populations
assume a single, isolated and panmictic population (ie a Wright-Fisher model). While this …

Phylogeographic methods aim to infer migration trends and the history of sampled lineages
from genetic data. Applications of phylogeography are broad, and in the context of …

This paper provides an overview of the contentious issue of global megafaunal extinctions in
the Late Quaternary. The main proposed causes are 'overkill', environmental change or a …

The invention of agriculture is widely assumed to have driven recent human population
growth. However, direct genetic evidence for population growth after independent …