Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …

Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …

Recent studies on enzymes and reader proteins for histone crotonylation support a function
of histone crotonylation in transcription. However, the enzyme (s) responsible for histone …

Histone acetylation is generally associated with active chromatin, but most studies have
focused on the acetylation of histone tails. Various histone H3 and H4 tail acetylations mark …

The precise, temporal order of gene expression during development is critical to ensure
proper lineage commitment, cell fate determination, and ultimately, organogenesis …

Transcription factors and chromatin-remodeling complexes are key determinants of
embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the …

The WDR5 subunit of the MLL complex enforces active chromatin and can bind RNA; the
relationship between these two activities is unclear. Here we identify a RNA binding pocket …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …

Pluripotent stem cells, like embryonic stem cells (ESCs), have specialized epigenetic
landscapes, which are important for pluripotency maintenance. Transcription factor …

Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …