Last year brought a significant advance in asthma management, unyielding to the pressure
of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell …

The “epithelial barrier hypothesis” proposes that the exposure to various epithelial barrier–
damaging agents linked to industrialization and urbanization underlies the increase in …

Pollution in the world and exposure of humans and nature to toxic substances is
continuously worsening at a rapid pace. In the last 60 years, human and domestic animal …

The study of epigenetics has improved our understanding of mechanisms underpinning
gene‐environment interactions and is providing new insights in the pathophysiology of …

Allergic diseases, characterized by a broad spectrum of clinical manifestations and
symptoms, encompass a significant category of IgE-mediated atopic disorders, including …

In the past 2 years, there continue to be advances in our understanding of the genetic and
epigenetic underpinnings of atopy pertaining to disease risk and disease severity. The joint …

Air pollution is a serious threat to our health and has become one of the major causes of
many diseases including cardiovascular disease, respiratory disease, and cancer. The …

The epigenome is at the intersection of the environment, genotype, and cellular response.
DNA methylation of cytosine nucleotides, the most studied epigenetic modification, has been …

Allergic asthma is a frequently encountered and well described asthma phenotype.
However, its precise mechanisms are less known. The tools for targeted selection of patients …

The astounding number of genetic variants revealed in the 15 years of genome-wide
association studies of asthma has not kept pace with the goals of translational genomics …