Extracellular matrix remodeling: the common denominator in connective tissue diseases possibilities for evaluation and current understanding of the matrix as more …
MA Karsdal, MJ Nielsen, JM Sand… - Assay and drug …, 2013 - liebertpub.com
Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …
[HTML][HTML] Should subchondral bone turnover be targeted when treating osteoarthritis?
OBJECTIVE: Osteoarthritis (OA) is the most common form of arthritic disease, and it is a
major cause of disability and impaired quality of life in the elderly. OA is a complex disease …
major cause of disability and impaired quality of life in the elderly. OA is a complex disease …
[图书][B] Biochemistry of collagens, laminins and elastin: structure, function and biomarkers
M Karsdal - 2023 - books.google.com
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third
Edition provides current data on key structural proteins (collagens, laminins, and elastin) …
Edition provides current data on key structural proteins (collagens, laminins, and elastin) …
Type I collagen
K Henriksen, MA Karsdal - Biochemistry of collagens, laminins and elastin, 2024 - Elsevier
In bone, skin, and connective tissues, type I collagen is not only the most abundant collagen,
but it is also essential for tissue integrity. Type I collagen is an interstitial matrix molecule that …
but it is also essential for tissue integrity. Type I collagen is an interstitial matrix molecule that …
Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases
W Hui, GJ Litherland, MS Elias, GI Kitson… - Annals of the …, 2012 - ard.bmj.com
Objectives To investigate the effect of leptin on cartilage destruction. Methods Collagen
release was assessed in bovine cartilage explant cultures, while collagenolytic and …
release was assessed in bovine cartilage explant cultures, while collagenolytic and …
A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed …
N Barascuk, SS Veidal, L Larsen, DV Larsen… - Clinical …, 2010 - Elsevier
OBJECTIVES: Accumulation of extracellular matrix (ECM) components and increased matrix-
metalloprotease (MMPs) activity are hallmarks of fibrosis. We developed an ELISA for …
metalloprotease (MMPs) activity are hallmarks of fibrosis. We developed an ELISA for …
A novel marker for assessment of liver matrix remodeling: an enzyme-linked immunosorbent assay (ELISA) detecting a MMP generated type I collagen neo-epitope …
DJ Leeming, Y He, SS Veidal, QHT Nguyen… - Biomarkers, 2011 - Taylor & Francis
A competitive enzyme-linked immunosorbent assay (ELISA) for detection of a type I collagen
fragment generated by matrix metalloproteinases (MMP)-2,-9 and-13, was developed (CO1 …
fragment generated by matrix metalloproteinases (MMP)-2,-9 and-13, was developed (CO1 …
Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
MA Karsdal, SH Madsen, C Christiansen… - Arthritis research & …, 2008 - Springer
Introduction Physiological and pathophysiological cartilage turnover may coexist in articular
cartilage. The distinct enzymatic processes leading to irreversible cartilage damage …
cartilage. The distinct enzymatic processes leading to irreversible cartilage damage …
MMP mediated degradation of type VI collagen is highly associated with liver fibrosis–identification and validation of a novel biochemical marker assay
SS Veidal, MA Karsdal, E Vassiliadis, A Nawrocki… - PloS one, 2011 - journals.plos.org
Background and Aims During fibrogenesis, in which excessive remodeling of the
extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix …
extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix …
[HTML][HTML] MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation–divergence in pathways leading to aggrecanase and MMP-mediated …
BC Sondergaard, N Schultz, SH Madsen… - Osteoarthritis and …, 2010 - Elsevier
OBJECTIVES: Matrix metalloproteinases (MMPs) and aggrecanases are essential players in
cartilage degradation. However, the signaling pathways that results in MMP and/or …
cartilage degradation. However, the signaling pathways that results in MMP and/or …