Abstract Purpose of Review Here, we discuss the origin of chondrocytes, their destiny, and
their plasticity in relationship to bone growth, articulation, and formation of the trabeculae …

The tissue-resident skeletal stem cells (SSCs), which are self-renewal and multipotent,
continuously provide cells (including chondrocytes, bone cells, marrow adipocytes, and …

Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will
provide insights into skeletal development and genetic skeletal disorders and will generate …

Mesenchymal progenitors of the lateral plate mesoderm give rise to various cell fates within
limbs, including a heterogeneous group of muscle-resident mesenchymal cells. Often …

Skeletal stem cells (SSCs) that are capable of self-renewal and multipotent differentiation
contribute to bone development and homeostasis. Several populations of SSCs at different …

Pivotal in many ways for human health, the control of adult bone mass is governed by
complex, incompletely understood crosstalk namely between mesenchymal stem cells …

Endochondral bone formation is an important pathway in fracture healing, involving the
formation of a cartilaginous soft callus and the process of cartilage-to-bone transition. Failure …

Notch Signaling Regulates the Chondrogenic Potential of Both Articular Chondrocytes and
Their Progenitors During Expansion - PMC Back to Top Skip to main content NIH NLM Logo …

While formation and regeneration of the skeleton have been studied for a long period of
time, significant scientific advances in this field continue to emerge based on an unmet …

Hypertrophic chondrocytes are found at unique locations at the junction of skeletal tissues,
cartilage growth plate, articular cartilage, enthesis and intervertebral discs. Their role in the …