When the body responds to an infectious insult, it initiates an immune response to eliminate
the pathogen. The hallmark of the immune response is an inflammatory cascade that can …

Intercellular communication depends on many factors, including proteins released via the
classical or non-classical secretory pathways, many of which must be properly folded to be …

Following myocardial infarction, tissue repair is mediated by the recruitment of monocytes
and their subsequent differentiation into macrophages. Recent findings have revealed the …

Aims Ischemic heart disease is a leading cause of death and disability worldwide. Despite
recent advances, there is no effective therapy for preventing myocardial ischemia …

DNA-based nanoconstructs possess great potential for biomedical applications. However,
the in vivo behavior of such constructs at the microscopic tissue/cell level as well as their …

Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs. However, its clinical
use has been hampered due to the development of cardiotoxicity. Vitexin, which is the active …

Reperfusion after acute myocardial infarction further exaggerates cardiac injury and adverse
remodeling. Irrespective of cardiac cell types, loss of specifically the α isoform of the protein …

BACKGROUND: Myocardial dysfunction has been associated with inflammation and
cytokine modulation. OBJECTIVES: The study objective was to understand the role of …

The term “inflammageing” was introduced in 2000, with the aim of describing the chronic
inflammatory state typical of elderly individuals, which is characterized by a combination of …

Reactive oxygen species (ROS) play a crucial role in the pathophysiology of ischemic heart
disease by causing cardiac dysfunction and cell death. Several redox-sensitive anti-and pro …