Traditional proteomics methodology allows global analysis of protein abundance but does
not provide information on the regulation of protein activity. Proteases, in particular, are …

Peptide microarrays have become increasingly accessible in recent years and as a result,
more widely applied. Beyond its initial utility in substrate profiling, researchers are adopting …

Because of the abnormal upregulation of matrix metalloproteinase (MMP) activities in
tumors, MMP inhibitors (MMPIs) are validated anticancer drug candidates. We identified …

Cu (I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) is often utilized in medicinal chemistry
to make the triazole moiety as it acts as a non-classical bioisostere of the peptide bond. This …

The recognition that the successful clinical use of MMP inhibitors will require quantitative
correlation of MMP activity with disease type, and to disease progression, has stimulated …

Protein phosphorylation and dephosphorylation play an important role in regulation of
intracellular signal transduction pathways in the biological system. A key step in the …

Two important challenges in microplate instrumentation are to achieve full well sample
coverage and complete mixing. An effective approach of using superhydrophobic rods to …

Protein phosphorylation is one of the most important and well-studied posttranslational
modifications. Aberrant phosphorylation causes a wide spectrum of diseases, including …

While biomedical investigation has greatly advanced, investigators have lost touch with and
inadvertently corrupted significant nomenclature at the foundation of their science …

In recent years, array‐based technologies, including DNA microarrays and protein‐detecting
microarrays have been getting more attractive and promising as high‐throughput …